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In the context of PAR4 activation, SKI-606 lessened platelet spreading in both equally genotypes, While major genotype distinctions had been nonetheless observed. These information propose that Src signaling in KI platelets leads to Increased platelet spreading and that inhibition of Src is ample to normalize platelet spreading to wild-variety levels.

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are proven. (D) Western blot Evaluation of isolated platelets identified no adjust in total expression of integrin α

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